The teratogenic effect of antiepileptic drugs was suggested by Meadow in 1968, who associated minor facial anomalies in 14–33% of the children exposed. Some malformative syndromes are associated with specific drugs, such as phenytoin (PHT), trimethadione, valproate (VPA), primidone, carbamazepine (CBZ), and phenobarbital. Most of these syndromes have been related to common metabolic pathways, high [...]